Canceled: The unhappy chaperone

DRA lecture held by Professor Sara Linse, Lund University, Sweden

The talk will review findings of increased solubility of amyloid proteins in the presence of the chaperone DNAjb6. Solubility being an equilibrium property requires a thermodynamic explanation, and one such explanation is put forward as the unhappy chaperone hypothesis. We will outline the experimental evidence needed to falsify or support this hypothesis and show examples of data for four clients: amyloid β peptide and tau from Alzheimer’s disease, α-synuclein from Parkinson’s disease and IAPP from diabetes type II.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Céline Galvagnion, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.