Design and Discovery of Positive Allosteric Modulators Targeting Ionotropic Glutamate Receptors

DRA lecture held by Associate Professor Pierre Francotte, University of Liège, Belgium

Glutamatergic receptors, key players in brain function, are promising therapeutic targets. The AMPA receptor positive allosteric modulators (AMPARpams) enhance glutamate action and hold potential for treating neurological and psychiatric disorders. The Laboratory of Medicinal Chemistry (University of Liège) has developed original AMPARpams of the 1,2,4-benzothiadiazine 1,1-dioxide class. Collaborations with the University of Copenhagen enabled the design of super-affinity ligands and structural insights into their binding. Current work focuses on selective kainate receptor potentiators.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Anders Skov Kristensen and Professor Jette Sandholm Kastrup, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.