All G protein coupled receptors (GPCRs) were orphan receptors once upon a time

DRA lecture held by Professor David R. Greaves, Sir William Dunn School of Pathology, University of Oxford, UK

The human genome encodes around 800 GPCRs. The proteins encoded by these genes have a common organisation with seven transmembrane helical domains. Orphan GPCRs are defined as receptors for which we have not (yet) identified the physiological ligand. In my seminar I will talk about Class A GPCRs that are expressed by macrophages and how they regulate Inflammation. Over the last thirty years I have ‘de-orphanised’ several GPCRs and I am intrigued by the orphan receptor GPR84. I will talk about how we have been using chemical biology approaches to understand the roles that the GPR84 receptor might play in innate immune cell biology.

The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Professor Trond Ulven, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

The DRA lecture is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.