Transport of biomolecules to the brain and the role of tanycytes of the ME/ARH
DRA symposium
The recent success in therapeutic regulation of metabolism by compounds such as GLP-1 analogues, has demonstrated that it actually is possible to get larger biomolecules into the brain. The symposium will deal with how biomolecules such as peptides, antibodies and peptidomimetics may enter the brain, as well as the effects of therapeutic compounds on obesity and the role of the tanycytes of the median eminence in the transport of compounds such as GLP-1, to their targets.
Programme
| 13:30 | Introduction Birger Brodin, Department of Pharmacy, University of Copenhagen, Denmark |
| 13:45 | Endocytosis and Transcytosis of antibodies/receptors in the vascular endothelium Morten Schallburg Nielsen, Department of Biomedicine, Aarhus University, Denmark |
| 14:15 | Lipidized neuropeptides as potential tool for treatment of obesity, type 2 diabetes and neurodegeneration Lenka Maletínská, Institute of Organic Chemistry and Biochemistry of the CAS, Praha, Czech Republic |
| 14:45 | Coffee break |
| 15:00 | Generating human arcuate nucleus tanycytes and neurons from stem cells Zehra Caldwell, reNEW NNF Center for Stem Cell Medicine, University of Copenhagen, Denmark |
| 15:30 | Advancing Peptide-Based Drug Discovery in Metabolic Diseases at Gubra: Insights from the industry Anja Mosekjær Bengtsson, In Vitro and Pharmaceutical Research, Gubra Hørsholm, Denmark |
| 16:00-16:05 | Wrap up by Birger Brodin |
The symposium is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Professor Birger Brodin Larsen, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen.
The symposium is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.