Abstract by Rong Di

Amorphous drug delivery systems enhance the bioavailability of poorly water-soluble drugs by improving their solubility. To stabilize the unstable amorphous form of drugs, excipients like polymers or low molecular weight co-formers can be used, resulting in amorphous solid dispersions (ASDs) and co-amorphous systems (CAMS), respectively. This study investigated the influence of internal molecular interactions on ASDs by using a novel allyl-terminated semi-crystalline polymer, methoxy(polyethylene glycol)-block-poly(jasmine lactone) (mPEG-b-PJL), which allows for functionalization tailored to drug properties, enhancing drug-polymer interactions in ASDs. The results indicated that ASDs with enhanced drug-polymer interactions exhibit better miscibility, improved drug loading abilities, and superior physical stability, although dissolution performance did not significantly improve, suggesting a need for further study. Additionally, the research examined the effects of external mechanical forces, like grinding, on CAMS. The results showed that grinding can destabilize amorphous drugs, especially in CAMS at mixing ratios that contain excess components, highlighting the importance of optimizing mixing ratios to improve stability against external applied mechanical forces during manufacturing. This work sets the stage for more in-depth investigations into amorphous pharmaceutical formulations.