Subunit-selective NMDA receptor antagonists
DRA lecture held by Dr. Bernhard Wünsch, Professor at the Department of Pharmaceutical and Medicinal Chemistry, University of Munster, Germany.
The development of novel antagonists of the ionotropic NMDA receptor, in particular on GluN2B subtype-selective antagonists interacting with the ifenprodil binding site of the GluN2B subunit is presented. General principles used in Medicinal Chemistry, such as late-stage diversification, structure-affinity relationships and considering pharmacokinetic aspects at an early stage of development will be reported.
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The lecture is organised on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Associate Professor Rasmus Prætorius Clausen, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.
The DRA lecture is free of charge and open for attendance by all interested parties.