Novel insights to the interactions of GPCRs with lipids, ligands and signaling proteins

DRA symposium

The latest structural and pharmacological studies on G Protein-Coupled Receptors (GPCRs) have revealed new connections between the receptors, their ligands, and their signaling proteins. In this symposium, three presenters will showcase their works that have deepened our understanding of GPCR structure and function. Martin Caffrey (Trinity College Dublin) will tell us about his game-changing work on the lipidic cubic phase that enabled the crystallization of many GPCRs. David Gloriam (University of Copenhagen) will present the deorphanisation of multiple orphan GPCRs by identifying new GPCR-peptide pairs. Concluding the session, Martha Sommer (Charité Universitätsmedizin Berlin) will take us on an in-depth exploration of the interactions between GPCRs and β-arrestins.

Programme

14:00  Introduction
Stefan Mordalski, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
14:10 Lipid Mesophases for Membrane Protein Structure, Function and Drug Design Studies
Martin Caffrey, Membrane Structural & Functional Biology Group, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland
Martin Caffrey abstract
14:55 Coffee break
15:15 Novel pairings in the human peptide-receptor signaling system
David E. Gloriam, Department of Drug Design and Pharmacology, University of Copenhagen, Denmark
David Gloriam abstract
16:00 Revisioning how GPCRs activate and bind arrestins
Martha Sommer, Institute of Medical Physics and Biophysics, Charité - Universitätsmedizin Berlin, Germany
Martha Sommer abstract

      


The symposium is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, and the ILF GPCR Cluster, by Stefan Mordalski, Flemming Steen Jørgensen and David Gloriam, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen..

The DRA symposium is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.