Novel insights into rapid antidepressant mechanisms – University of Copenhagen

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Novel insights into rapid antidepressant mechanisms

Lecture by Dr. Tomi Rantamäki, Laboratory of Neurotherapeutics, Molecules, Cells and Systems, Research Program of the Faculty of Biological End Environmental Sciences, University of Helsinki, Finland

My lab investigates neurobiological mechanisms underlying rapid antidepressant effects in animal models. We recently discovered that isoflurane, a commonly used volatile anesthetic, rapidly regulates key molecular signaling events implicated in rapid antidepressant actions produced by subanesthetic ketamine: activation of BDNF receptor TrkB and inhibition of GSK3b (Antila et al, Scientific Reports, 2017). These findings provide novel insights into the putative antidepressant potential of isoflurane and other anesthetics (e.g. Langer et al, 1995). Our unpublished data demonstrate that nitrous oxide (laughing gas), another putative rapid-acting antidepressant, bring very similar acute effects on TrkB and GSK3b signaling. In this talk I will present our theoretical framework regarding the shared principles how rapid-acting antidepressants target these signaling events.

The lecture is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy by Petrine Wellendorph and Anders Bue Klein, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

Participation is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.