Applications of neutron reflectometry to address challenges in physical pharmacy – University of Copenhagen

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Applications of neutron reflectometry to address challenges in physical pharmacy

Lecture held by Dr Richard Campbell, Institut Laue-Langevin, France


Neutron reflectometry is a sophisticated technique that can be used to probe the structure and composition of soft matter systems at interfaces.  The technique is both non-invasive and non-destructive in nature and can exploit isotopic contrast variation to provide unique information about interaction mechanisms involving model biological membranes. With the commissioning of more powerful instruments, scope emerges to use the technique to meet new challenges both in terms of the characterization of components with lower scattering contrast or greater kinetic resolution than was previously possible.  This seminar opens with a description of the latest capabilities of the technique and presents the case that there are three different ways in which it can be exploited to good effect in the provision of information about systems of key relevance in physical pharmacy.  Three examples of how these different applications of the same technique have been exploited to provide important information in pharmaceutical projects are then presented: (1) membrane interactions of short, designed antimicrobial peptides, (2) membrane attachment of liquid crystalline nanocarriers, and (3) membrane binding of anti-cancer drugs.

The lecture is arranged on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, Faculty of Health and Medical Sciences, University of Copenhagen, by Martin Malmsten and Kathryn Browning, Department of Pharmacy.

The arrangement is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.