Novel kinase inhibitors derived from β-carboline alkaloids – University of Copenhagen

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Novel kinase inhibitors derived from β-carboline alkaloids

Lecture held by professor Franz Bracher, Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Germany

Natural products are a rich source of lead structures for drug development. In the last decade we performed extensive investigations on the potential of β-carboline alkaloids as lead structures for the development of selective kinase inhibitors. Accompanied by comprehensive research on novel synthetic approaches towards the β-carboline and related scaffolds, we developed new and selective inhibitors targeting protein kinases like DYRK1A, CLK1, PIM, and BMP2K, which are of potential therapeutic interest for various diseases (cancer, viral and protozoal infections, inflammation, neuronal disorders).

Selected ref.: Nature Communications, 2016, 7:11320; PLOS One 2015, 10(7): e0132453; J. Med. Chem. 2012, 55, 403-413.

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The lecture is organized on behalf of the graduate programme in pharmaceutical sciences, Drug Research Academy, by Jesper L. Kristensen, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen.

Participation is free of charge and open for attendance by all interested parties. It is not necessary to pre-register.