Abstract – University of Copenhagen

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DRA > Activities > 2017 > PhD Defences > PhD Defence by Lærke Østergaard Arnfast > Abstract

Abstract

PhD thesis abstract by Lærke Arnfast

Solid form engineering in melt extrusion

With the increasing knowledge and availability of advanced diagnostic tests that can reveal important metabolic differences between sub-populations and well as between individuals, the need for further personalization in dose and combinations of medicinal products increases.

Several of the technologies envisioned for the manufacture of personalized medicines rely on melt extrusion. For these platforms to succeed, a better understanding of the formulation space within melt extrusion as well as innovative solutions in terms of drug-drug combinations is needed. In this thesis, an explorative analysis of two innovative formulation concepts has been performed with the purpose of expanding the current knowledge space within formulation and process development of melt extruded pharmaceuticals, through studying the effect of drug-polymer interactions on the solid form of the drug and the processability of the formulation.